Nature cancerGlioblastomaHumansTumor MicroenvironmentOncolytic VirusesOncolytic Virotherapy
Retargeted oncolytic viruses engineered to remodel the tumor microenvironment for glioblastoma immunotherapy.
Federico Giovannoni, Craig A Strathdee, Camilo Faust Akl, Brian M Andersen, Zhaorong Li, Hong-Gyun Lee, María Florencia Torti, Joseph M Rone, Pere Duart-Abadia, Martina Molgora, Linxing Kong, Michael Floyd, Jian Teng, Yulia Gyulakian, Peter Grzesik
Published: 202510.1038/s43018-025-01070-6
Abstract
Glioblastoma (GBM) is an aggressive, immunotherapy-resistant brain tumor. Here, we engineered an oncolytic virus platform based on herpes simplex virus 1 for GBM viroimmunotherapy. We mutated the highly cytopathic MacIntyre strain to increase spread…
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