Nature metabolism
Lamin A/C-regulated cysteine catabolic flux modulates stem cell fate through epigenome reprogramming.
Yinuo Wang, Haojie Shi, Janina Wittig, Yonggang Ren, Julio Cordero, Matthias Dewenter, Jessica Mella, Abigail Buchwalter, Johannes Backs, Thomas Wieland, Joerg Heineke, Ingrid Fleming, Sofia-Iris Bibli, Gergana Dobreva
Published: 202610.1038/s42255-025-01443-2
Abstract
Spatiotemporal changes in the nuclear lamina and cell metabolism shape cell fate, yet their interplay is poorly understood. Here we identify lamin A/C as a key regulator of cysteine catabolic flux essential for proper cell fate and longevity. Its los…
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