Nature metabolismLiver NeoplasmsCarcinomaHepatocellularAnimalsMice
Tumour-associated macrophages serve as an acetate reservoir to drive hepatocellular carcinoma metastasis.
Li Shen, Shenghao Wang, Chao Gao, Qin Li, Shuya Feng, Weiyan Sun, Xu Liu, Yiyi Ba, Yihui Chu, Yu Zhou, Junjie Pan, Hao Xu, Xu Zhang, Wenwei Zhu, Lunxiu Qin
Published: 202510.1038/s42255-025-01393-9
Abstract
Increased acetyl-coenzyme A (acetyl-CoA) generation facilitates cancer metastasis and represents a critical metabolic characteristic of metastatic cancers. To maintain high acetyl-CoA levels, cancer cells often enhance the uptake of acetate for acety…
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