Communications chemistry
Identification of an αvβ3-targeting bicyclic peptide with atypical norArg-Gly-Asp sequence.
Haijian Yang, Hui Pan, Ting Ran, Wenyan Dong, Wencong Pan, Jianhui Tan, Jingjing Sun, Roderich D Süssmuth, Wu Su, Guiyang Yao
Published: 202610.1038/s42004-026-01886-y
Abstract
Bicyclic peptides, which integrate the advantageous properties of small molecules and antibodies, have emerged as a promising class of therapeutic candidates. In particular, integrin αvβ3 serves as a critical molecular target for cancer diagnosis and…
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