Communications biology
A pathogenic mutation in α-SNAP impairs membrane lipid binding by concealing a critical hydrophobic loop.
Maxs Méndez-Ruette, Mauricio Bedoya, Bryan Hinrichsen, Roberto Henzi, Camila Muñoz-Gutiérrez, Cristián Parga, Camilo Muñoz, Guillermo Márquez, Rosa Iris Muñoz, Soledad Sandoval, Breyan H Ross, Juan Pablo Vivar, Gonzalo A Mardones, Sebastián Brauchi, Úrsula Wyneken
Published: 202610.1038/s42003-026-09578-y
Abstract
The soluble N-ethylmaleimide-sensitive factor attachment protein alpha (α-SNAP) is essential for vesicle trafficking, coordinating trans-SNARE zippering and cis-SNARE disassembly. α-SNAP also regulates autophagy, apoptosis, calcium signaling, and AMP…
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