Communications biology
A paraventricular hypothalamic control of social stress susceptibility by targeting brown adipose tissue β3 adrenoceptor.
Xinyu Du, Jin Zhang, Qian Wang, Dongyu Zhou, Wenxin Zhang, Lingzhen Song, Mengqiao Cui, Ting Ge, Xiaojing Zhai, Yumei Yu, Junxia Yang, Ankang Hu, Hongxing Zhang, Jun-Li Cao, Zhou Wu
Published: 202610.1038/s42003-026-09574-2
Abstract
Adipose tissue disturbance underlies the pathogenesis of major depressive disorder (MDD); however, the underlying neural and molecular mechanisms remain elusive. Utilizing a social defeat stress mouse model of MDD, we identified a paraventricular hyp…
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