Communications biology
MHC1-TIP enables single-tube multimodal immunopeptidome profiling and uncovers intratumoral heterogeneity in antigen presentation.
Mayukha Bathini, Diana Bocaniciu, Fraser D Johnson, Rick C P de Jong, Fengchao Yu, Vincenzo Davide Aloi, Marije C Kuiken, Janniek R Mors, Lisanne Giebel, Julien Champagne, Onno Bleijerveld, Reuven Agami, Krijn K Dijkstra, Daniela S Thommen, Alexey I Nesvizhskii
Published: 202610.1038/s42003-026-09570-6
Abstract
Profiling antigens presented on MHC class I molecules on the cell surface is essential to identify candidate antigens for targeted and personalized immunotherapies. However, mass spectrometry-based immunopeptidomics has traditionally been limited by…
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