Communications biology
CHK1 inhibition rescues abnormal glycogen buildup in a Caenorhabditis elegans model for glycogen storage disease III.
Hiba Daghar, Blake Pyman, Claudia Maios, James Doyle, Ethan Perlstein, Éric Samarut, J Alex Parker
Published: 202610.1038/s42003-026-09535-9
Abstract
Glycogen Storage Disease Type III (GSDIII) is a rare genetic disorder caused by mutations in the AGL gene, leading to a deficiency in the glycogen debranching enzyme. This results in the accumulation of abnormal glycogen in various tissues, causing a…
Preview only. Read the full abstract at the source