Communications biology
MAT2A enhances PARN transcription via SRF to accelerate glycolysis and drive malignant progression in osteosarcoma.
Zhinan Ren, Haoming Chen, Qi Qiao, Zehao Xie, Jianhua Hu, Canjun Zeng, Yi Shen, Runguang Li
Published: 202610.1038/s42003-026-09518-w
Abstract
Osteosarcoma lacks effective molecular targets, and the biological role of MAT2A in this disease remains unclear. Here we show that MAT2A drives osteosarcoma progression by increasing the transcription of the downstream gene PARN. MAT2A interacts wit…
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