Communications biology
ZIP8 loss impairs macrophage-mediated phagolysosomal removal of bacteria and is overcome by butyrate supplementation.
Deandra R Smith, Sabah Haq, Meng Niu, Sunayana Malla, Rajib Saha, Ashley Peer, Piero Bianco, Svetlana Romanova, Derrick R Samuelson, Daren L Knoell
Published: 202610.1038/s42003-025-09504-8
Abstract
Zinc deficiency impacts billions of people and contributes significantly to the increased incidence of community-acquired pneumonia worldwide. Myeloid cells require the zinc transporter ZIP8 for proper host defense. Previously, we observed that infec…
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