Communications biology
Hypoxia leads to reduced mito-nuclear gene expression and increased mtDNA transcriptional pausing in human cells.
Noam Shtolz, Sarah Dadon, Dan Mishmar
Published: 202610.1038/s42003-025-09457-y
Abstract
Mitochondria respond to various stresses. Nevertheless, the regulation of this response while considering coordination between mitochondrial (mtDNA)- and nuclear DNA (nDNA)-encoded gene expression has been overlooked. Our RNA-seq analysis of 18 human…
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