Communications biology
HOXA2 exerts anti-renal fibrosis effects through reducing endoplasmic reticulum stress via the upregulation of SIRT1.
Xin Li, Tian-Kui Ma, Xiao-Xu Deng, Sang Hai, Fang Ma, Yun Zou, Qi Yang, Hui Lyu, Yu-Xi Li, Hong Ding
Published: 202510.1038/s42003-025-09453-2
Abstract
Relieving renal fibrosis are promising therapeutic strategies for chronic kidney disease (CKD). Here we showed that decreased homeobox A2 (HOXA2) expression with excessive ER stress activation were observed in the renal tissues of UUO mice establishe…
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