Communications biology
Sae2 integrates CDK and checkpoint phosphorylation to coordinate MRX cleavage with checkpoint attenuation.
Erika Casari, Marco Gnugnoli, Paolo Pizzul, Renata Tisi, Maria Pia Longhese
Published: 202510.1038/s42003-025-09424-7
Abstract
Yeast Sae2 plays a dual role in the DNA damage response by suppressing Rad53 activation and stimulating DNA end clipping via the MRX complex. Using AlphaFold3-based modeling and mutational analysis, here we show that Mec1/Tel1-dependent phosphorylati…
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