Communications biology
PRICKLE3 protects VANGL proteins from CK1-mediated phosphorylation and RNF43-mediated degradation.
Katarzyna A Radaszkiewicz, Tomasz W Radaszkiewicz, Pavla Kolářová, Petra Paclíková, Kristína Gömöryová, Šárka Novotná, Lorena Agostini Maia, Tereza Číhalová, Yao Le, Tomáš Bárta, Kateřina Hanáková, Anna Hýsková, Konstantinos Tripsianes, Zbyněk Zdráhal, Christoph Winkler
Published: 202510.1038/s42003-025-09422-9
Abstract
The PRICKLE proteins (PRICKLE1-PRICKLE4) play essential roles in the WNT/planar cell polarity (WNT/PCP) pathway in vertebrates. This signaling system governs cell polarity, tissue architecture, and coordinated cell movements, yet the specific roles a…
Preview only. Read the full abstract at the source