Communications biology
AcrIIA19 binds to the WED domain and inhibits various Cas9 orthologs at multiple stages.
Gi Eob Kim, So Yeon Lee, Yong Jun Kang, Hyo Bin Jin, Hyun Ho Park
Published: 202510.1038/s42003-025-09417-6
Abstract
Anti-CRISPR (Acr) proteins are natural inhibitors of clustered regularly interspaced short palindromic repeat (CRISPR)-CRISPR-associated protein (Cas) systems, providing valuable tools for regulating genome editing. Here, we present the crystal struc…
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