NPJ precision oncology
Translating spatial transcriptomic signatures in adenosquamous carcinoma into bulk prognostic biomarkers in lung adenocarcinoma: a bottom-up approach.
Keiichi Hatakeyama, Takuya Kawata, Koji Muramatsu, Takuma Oishi, Takeshi Nagashima, Ai Sakai, Terumi Nishimura, Keiichi Ohshima, Sumiko Ohnami, Shumpei Ohnami, Yuji Shimoda, Akane Naruoka, Koji Maruyama, Kenichi Urakami, Yasuto Akiyama
Published: 202610.1038/s41698-026-01297-1
Abstract
Spatial transcriptomics enables the detection of rare or transitional tumor states not captured by bulk transcriptomics or immunohistochemistry (IHC). However, translating these spatially defined states into clinically relevant biomarkers is challeng…
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