NPJ precision oncology
Multimodal single-cell profiling reveals crosstalk between macrophages and stromal cells in poor prognostic cholangiocarcinoma patients.
Lara Heij, Sikander Hayat, Konrad Reichel, Sidrah Maryam, Colm J O'Rourke, Xiuxiang Tan, Marlous van den Braber, Jan Verhoeff, Maurice Halder, Fabian Peisker, Georg Wiltberger, Jan Bednarsch, Daniel Heise, Julia Campello Deierl, Sven A Lang
Published: 202610.1038/s41698-026-01292-6
Abstract
Cholangiocarcinoma (CCA) is a deadly cancer, characterized by abundant stroma. The tumor microenvironment (TME) plays an important role in its aggressive behavior and poor response to therapeutics; however, the underlying pathways are unknown. To fil…
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