NPJ precision oncology
Ultrasensitive ctDNA monitoring reveals early predictors of immunotherapy response in advanced cancer.
Daisuke Nishizaki, Allison Law, Bailiang Li, Charles Abbott, Yi Chen, Suzanna Lee, Rachel Pyke, Kathleen Keough, Gregory A Daniels, Kay T Yeung, Sean M Boyle, Richard O Chen, Shumei Kato
Published: 202610.1038/s41698-026-01287-3
Abstract
Circulating tumor DNA (ctDNA)-based response assessment is appealing but limited by conventional analytical thresholds. We utilized a whole genome sequencing based, tumor-informed ultrasensitive ctDNA assay which tracked ~1800 somatic mutations to an…
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