NPJ precision oncology
Aligning computational pathology with clinical practice for colorectal cancer.
Elias Baumann, José F Carreño-Martínez, Ana Leni Frei, Javier García-Baroja, Mauro Gwerder, Amjad Khan, Rina Mehmeti, Jacob Hanimann, Philipp Zens, Heather E Dawson, Alessandro Lugli, Inti Zlobec
Published: 202510.1038/s41698-025-01119-w
Abstract
Open AccessThe pathology report in colorectal cancer (CRC) consists of more than 20 elements defined in guidelines such as the International Collaboration on Cancer Reporting (ICCR) guidelines. Recently, computational tools have been proposed to advance the CRC diagnostic routine, yet most lack clinically validated results and focus on only three report elements. This review gives an overview of the current gaps and will contribute to aligning computational pathology with clinical practice.