Scientific reports
Structural characterization of metal binding in human tyrosylprotein sulfotransferase 2, TPST2.
Minwoo Jin, Chaemin Noh, Jihyeong Yang, Hyunwoo Kim, Soo Bin Park, Yong-Chul Kim, Soo Hyun Eom
Published: 202610.1038/s41598-026-37189-4
Abstract
Tyrosylprotein sulfotransferases (TPSTs) catalyze O-sulfation of tyrosine residues on secreted and membrane proteins, but the molecular basis for their stimulation by metal ions remains unclear. We determined the structures of the catalytic domain of…
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