Scientific reports
Loss of the CoA-degrading enzyme NUDT19 exacerbates albuminuria and disrupts renal lipid homeostasis in high fat diet-fed mice.
Dominique C Saporito, Rachel D King, Schuyler D Vickers, Emily A Wyda, Sruthi Balaji, Saravanan Kolandaivelu, Neil Billington, Judy A King, Roberta Leonardi
Published: 202610.1038/s41598-026-36136-7
Abstract
Nudix hydrolase 19 (NUDT19) is a peroxisomal enzyme that hydrolyzes CoA species at the phosphodiester bond and has been linked to peroxisomal dysfunction in the context of diabetic kidney disease. Despite its predominant expression in mouse kidneys,…
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