Scientific reports
The role of the α7 nicotinic acetylcholine receptor in promoting M2 macrophage polarization at inflammatory sites.
Taiki Mihara, Hiroshi Tanabe, Yuma Nonoshita, Yuki Yamakawa, Tamaki Kurosawa, Masatoshi Hori
Published: 202610.1038/s41598-026-35757-2
Abstract
The α7 nicotinic acetylcholine receptor (α7nAChR) on macrophages exerts anti-inflammatory effects by suppressing the JAK/STAT and NF-κB pathways. Although the role of α7nAChR in immunoregulatory mechanisms in "individual" macrophages is established,…
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