Scientific reports
Rational redesign of high-activity G-quadruplex DNAzyme through flanking and looping of nucleobases.
Raphael I Adeoye, Nikhildas Babbudas, Matthew Birchenough, Francesca Giuntini, Femi J Olorunniji
Published: 202610.1038/s41598-026-35686-0
Abstract
G-quadruplex (G4) DNAzymes are guanine-rich oligonucleotides with intrinsic peroxidase-mimicking activity upon complexation with hemin, offering a promising alternative to protein-based enzymes in biosensing. However, their relatively low catalytic e…
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