Scientific reports
Chelesta-8,24-dien-3-ol in Ficus exasperata leaves enhances the prevention of sodium nitrite-induced hypoxia by binding to HIF-1 and NF-κB.
Dorcas Ibukun Akinloye, Ceaser Antiya Moses, Esther Ugo Alum, Theophilus Aghogho Jarikre, Toluwalase Ayobami Adeosun, Abdulazeez Timileyin Kolawole, Iyanu Solomon Awonaiya, Esther Oluwabusayomi Odeniyi, Oluseyi Adeboye Akinloye
Published: 202610.1038/s41598-026-35307-w
Abstract
In-silico and in-vivo methods were used to study Ficus exasperata leaves' n-hexane ethyl acetate fraction (NHEAF) phytochemicals that may protect against NaNO2-induced hypoxic stress. The impact of NHEAF on enzymatic and non-enzymatic antioxidants, t…
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