Scientific reports
Position effect variegation (PEV) as an aging clock: visualization of age-dependent loss of heterochromatin and longevity associated with enhanced heterochromatin.
Sesley Tedeschi, Talia Takahashi, Yash Vyavahare, Emma Clark, Logan Deutschmann, Raynord Leung, Kat Stanley, Liam C Hunt
Published: 202610.1038/s41598-025-34978-1
Abstract
The heterochromatin loss model of aging suggests there is an age-dependent reduction in epigenetic factors that form and maintain the heterochromatin state of chromosomes. Position Effect Variegation (PEV) can visually report phenotypes of heterochro…
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