Scientific reports
Characterization of motor and non-motor features associated with bilateral nigral degeneration due to A53T alpha-synuclein in female rats.
Laura Kondrataviciute, Minesh Kapadia, Hien Chau, Cherisse Tan, Polly Ou, Ritisha Mukherjee, Sarah Hui, Sabika Jafri, Jimmy George, Ivan Skelin, Taufik Valiante, Luka Milosevic, Lorraine V Kalia, Suneil K Kalia
Published: 202610.1038/s41598-025-34884-6
Abstract
Parkinson's disease (PD) is characterized by the loss of dopaminergic neurons in the substantia nigra (SN), accumulation of alpha-synuclein (a-Syn)-rich aggregates, and the development of both motor and non-motor symptoms. The absence of a cure for P…
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