Scientific reports
Thapsigargin enhanced chemotherapeutic sensitivity of irinotecan in the inflammation-induced colorectal cancer model in mice.
Sukanya Baruah, Manuj Kumar Bharali, Nabila Akhtara, Jaydeep Kumar Nath, Sabana Sargam Rahman, Shehnaz Siddika Rasid, Mitali Baidya, Epham Mayum Mohd Samir Khan, Ritu Mishra
Published: 202610.1038/s41598-025-34567-2
Abstract
The present study used an in-vivo inflammation-induced colorectal cancer (CRC) model to evaluate the additive effect of thapsigargin (TG) with the standard chemotherapy drug irinotecan (IRN). CRC was induced by AOM/DSS, and after 10th weeks, animals…
Preview only. Read the full abstract at the source