Scientific reportsHumansReceptorsN-Methyl-D-AspartateAutoantibodiesDendritic Spines
Pathogenic human autoantibodies against NMDA receptor alter dendritic spine size.
Shimpei Matsuda, Takayuki Mori, Mariko Kasai, Kuniko Kohyama, Tadayuki Shimada, Hiroshi Sakuma
Published: 202610.1038/s41598-025-34027-x
Abstract
Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis (NMDARE) is an autoimmune neurological disorder associated with anti-NMDAR antibodies (NMDAR-Ab), leading to synaptic dysfunction. While the effect of NMDAR-Ab on receptor internalization i…
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