Nature structural & molecular biology
Cereblon induces G3BP2 neosubstrate degradation using molecular surface mimicry.
Stefano Annunziato, Chao Quan, Etienne J Donckele, Ilaria Lamberto, Richard D Bunker, Mary Zlotosch, Laura Schwander, Anastasia Murthy, Lars Wiedmer, Camille Staehly, Michelle Matysik, Samuel Gilberto, Despina Kapsitidou, Daric Wible, Gian Marco De Donatis
Published: 202610.1038/s41594-025-01738-8
Abstract
Molecular glue degraders (MGDs) are small-molecule compounds that divert E3 ligases to degrade nonnatural substrates called neosubstrates. Clinically effective MGDs bind cereblon (CRBN), a substrate receptor of the Cullin 4-RING E3 ubiquitin ligase (…
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