Nature structural & molecular biology
Redox-driven ADAR1 activation promotes Okazaki fragment maturation and DNA replication integrity.
Bin Chen, Guangchao Sun, Jake A Kloeber, Huaping Xiao, Yaobin Ouyang, Fei Zhao, Ya Li, Shilin Xu, Sonja Dragojevic, Zheming Wu, Shouhai Zhu, Yiqun Han, Ping Yin, Xinyi Tu, Hongran Qin
Published: 202610.1038/s41594-025-01736-w
Abstract
Okazaki fragment maturation requires efficient removal of RNA primers to form a continuous lagging strand, yet how mismatched primers introduced by error-prone primase are corrected remains unresolved. Here, we show that physiological levels of react…
Preview only. Read the full abstract at the source