Nature structural & molecular biologyDNA (Cytosine-5-)-MethyltransferasesDNA MethylationDNA Methyltransferase 3ACryoelectron MicroscopyNucleosomes
Mechanisms of DNMT3A-3L-mediated de novo DNA methylation on chromatin.
Yan Yan, X Edward Zhou, Stacey L Thomas, Minmin Liu, Gan-Qiang Lai, Evan J Worden, Peter A Jones, Ting-Hai Xu
Published: 202610.1038/s41594-025-01704-4
Abstract
De novo DNA methylation is mediated by DNA methyltransferases DNMT3A and DNMT3B, in cooperation with the catalytically inactive paralogs DNMT3L and DNMT3B3. DNMT3L is predominantly expressed in embryonic stem cells to establish methylation patterns a…
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