Nature neuroscience
Phosphorylated tau exhibits antimicrobial activity capable of neutralizing herpes simplex virus 1 infectivity in human neurons.
William A Eimer, Alex S Rodriguez, Michael T DeFao, Simon Ehricke, Joseph Park, Deepak K Vijaya Kumar, Nanda K Navalpur Shanmugam, Sanjana Singh, Tara Sawhney, Robert D Moir, Rudolph E Tanzi
Published: 202510.1038/s41593-025-02157-0
Abstract
Tau is a microtubule-associated cytoskeletal protein, which, when hyperphosphorylated and aggregated, can result in a myriad of different tauopathies, including Alzheimer's disease (AD). We previously showed that the principal component of senile pla…
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