Nature neuroscience
Munc18 modulates syntaxin phase separation to promote exocytosis.
Qing Pei, Qixin Chen, Zhiqi Tian, Le Zhu, Yang Chen, Jihong Gong, Shen Wang, Yijuan Xiang, John S Khamo, Jiaqi Fan, Yi Rong, Yi Yu, Yuyang Qin, Shiping Wu, Youssef Faragalla
Published: 202510.1038/s41593-025-02140-9
Abstract
The soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) protein syntaxin mediates neuronal exocytosis and self-assembles into large clusters in the plasma membrane. The formation and function of these clusters, and whether t…
Preview only. Read the full abstract at the source