Nature neuroscienceHumansMaleFemaleMiddle AgedAdult
Multi-region m6A epitranscriptome profiling of the human brain reveals spatial and temporal variation and enrichment of disease-associated loci.
Andrew M Shafik, Yong Peng, Zijie Zhang, Chen Chang, Pingluan Wang, Junghwa Lim, Hongjun Song, Chuan He, Mengjie Chen, Peng Jin
Published: 202610.1038/s41593-025-02112-z
Abstract
N6-methyladenosine (m6A) is a major RNA modification in the brain, regulating neural processes and contributing to disease mechanisms. Despite its importance, regional, age-specific and sex-specific m6A patterns in the human brain are still poorly de…
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