Nature neuroscienceSchizophreniaHumansChromatinNeuronsBrain
The neuronal chromatin landscape in brains from individuals with schizophrenia is linked to early fetal development.
Kiran Girdhar, Jaroslav Bendl, Andrew Baumgartner, Karen Therrien, Sanan Venkatesh, Rachel Bercovitch, Deepika Mathur, Pengfei Dong, Samir Rahman, Steven P Kleopoulos, Ruth Misir, Sarah M Reach, Pavan K Auluck, Stefano Marenco, David A Lewis
Published: 202510.1038/s41593-025-02081-3
Abstract
Noncoding variants increase neuropsychiatric disease risk, but our understanding of their cell-type-specific role remains incomplete. We conducted large-scale chromatin accessibility profiling of neurons and non-neurons from 2 neocortical regions in…
Preview only. Read the full abstract at the source