Nature methods
Systematic evaluation of computational tools for multitype RNA modification detection using nanopore direct RNA sequencing.
Tingting Luo, Moping Xu, Miao Wang, Faying Chen, Jiejun Shi
Published: 202510.1038/s41592-025-02974-y
Abstract
Nanopore direct RNA sequencing offers a versatile approach for detecting multiple types of RNA modifications at a single-base resolution. In this study, we systematically evaluate 86 computational tools for detecting six RNA modifications (m6A, Ψ, m5…
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