Nature methodsHumansExonsAnimalsAcyclovirGene Expression Regulation
A portable poison exon for small-molecule control of mammalian gene expression.
Qian Hou, Maxim Oleynikov, Xiaohan Mei, Linghao Dong, Timo Hagen, Samie R Jaffrey
Published: 202510.1038/s41592-025-02860-7
Abstract
The ability to precisely control gene expression using small-molecule drugs is a valuable tool in research and has important therapeutic potential. However, existing systems are often limited by the toxicity of the drugs and the need to alter gene se…
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