Nature medicine
Abemaciclib in meningiomas with somatic NF2 or CDK pathway alterations: the phase 2 Alliance A071401 trial.
Priscilla K Brastianos, Katharine Dooley, Susan Geyer, Elizabeth R Gerstner, Timothy J Kaufmann, A John Iafrate, Maria Martinez-Lage, Mohammed Milhem, Mary Roberta Welch, Thomas J Kaley, Jan Drappatz, Amy Chan, Priya Kumthekar, Carlos Kamiya Matsuoka, Roy E Strowd
Published: 202610.1038/s41591-025-04141-4
Abstract
Systemic treatments are limited for patients with meningiomas that have progressed after surgery or radiation. Loss of NF2 and CDKN2A/CDKN2B is common in higher-grade meningiomas and promotes progression in preclinical models. We evaluated the effica…
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