Nature medicine
Genotype-stratified adjunctive dexamethasone for tuberculous meningitis in HIV-negative adults: a randomized controlled phase 3 trial.
Joseph Donovan, Nguyen Duc Bang, Huu Khanh Trinh Dong, Dang Trung Nghia Ho, Thi Anh Thu Nguyen, Thi Thu Hiep Nguyen, Hong Bao Ngoc Lam, Vo Khac Nguyen Phung, Truc Thanh Nguyen, Ho Hong Hanh Nguyen, Kieu Nguyet Oanh Pham, Dang Anh Thu Do, Thi Mai Trang Nguyen, Thi Minh Ha Dang, Huu Lan Nguyen
Published: 202610.1038/s41591-025-04138-z
Abstract
Adjunctive corticosteroids such as dexamethasone are recommended in tuberculous meningitis treatment, despite modest and heterogeneous survival benefit. Leukotriene A4 hydrolase (LTA4H) genotypes associate with distinct intracerebral inflammatory phe…
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