Nature medicineHumansCirculating Tumor DNAMaleFemaleMiddle Aged
Circulating tumor DNA-guided adjuvant therapy in locally advanced colon cancer: the randomized phase 2/3 DYNAMIC-III trial.
Jeanne Tie, Yuxuan Wang, Jonathan M Loree, Joshua D Cohen, Rachel Wong, Timothy Price, Niall C Tebbutt, Val Gebski, David Espinoza, Matthew Burge, Sam Harris, James Lynam, Belinda Lee, Margaret M Lee, Daniel Breadner
Published: 202510.1038/s41591-025-04030-w
Abstract
Adjuvant chemotherapy in stage III colon cancer provides uncertain benefit at the individual level. Circulating tumor DNA (ctDNA) may help refine risk-adjusted treatment selection. In this multicenter, randomized, phase 2/3 trial, patients with stage…
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