Nature immunology
Spatial patterning of fibroblast TGFβ signaling underlies treatment resistance in rheumatoid arthritis.
Kartik Bhamidipati, Alexa B R McIntyre, Shideh Kazerounian, Gao Ce, Soon W Wong, Miles Tran, Sean A Prell, Rachel Lau, Vikram Khedgikar, Christopher Altmann, Annabelle Small, Roopa Madhu, Sonia R Presti, Ksenia S Anufrieva, Philip E Blazar
Published: 202610.1038/s41590-025-02386-2
Abstract
Treatment-refractory rheumatoid arthritis (RA) is a major unmet need, and the underlying mechanisms are poorly understood. To identify molecular determinants of refractory RA, we performed spatial transcriptomic profiling on synovial tissue biopsy sa…
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