Nature immunology
The differentiation and function of heterogeneous thymic dendritic cell subsets require signals provided by distinct thymocyte cell types.
Jayashree Srinivasan, Colin R Moore, Aparna Calindi, Bryan R Helm, Yilin Yang, John F Moore, Hilary J Selden, Cody N Heiser, Qi Liu, Ken S Lau, Lauren I R Ehrlich
Published: 202610.1038/s41590-025-02371-9
Abstract
Dendritic cells are essential for establishing thymic central tolerance; however, mechanisms supporting their homeostasis and activation remain unresolved. Through single-cell transcriptomics and functional assays, we identify seven thymic convention…
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