Nature immunologyHumansSepsisChildSingle-Cell AnalysisAdult
Single-cell multi-omic landscape reveals anatomical-specific immune features in adult and pediatric sepsis.
Qian Ye, Xiaofei Lai, Yuliang Liu, Zhengtao Zhang, Yueqiang Fu, Jie Luo, Chengjun Liu, Jun Duan, Hao Ding, Yuhan Liu, Zhi Ao, Yang Tao, Shanmu Ai, Wei Huang, Lei Jiang
Published: 202610.1038/s41590-025-02345-x
Abstract
The anatomical source of infection is a major determinant of sepsis outcomes; however, how distinct sites shape immunity remains unclear. Here we applied multi-omic profiling, integrating single-cell transcriptomics, single-cell T cell receptor and B…
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