Nature immunologyAnimalsProtein Serine-Threonine KinasesMiceUbiquitin-Protein LigasesKnockout
Pseudokinase STK40 limits T cell exhaustion through COP1-dependent degradation of AP1-family transcription factors.
Svetlana Altshuler-Keylin, Nicole Caduff, Isabel E Ishizuka, Rohit Reja, Katherine Nutsch, Chan Gao, Joy Wang, Ulrike Kaufmann, Mayra Cruz Tleugabulova, Elizabeth Dixon, Hannah Little-Hooy, Rachana Pradhan, Rosa Barreira da Silva, Teresita L Arenzana, Min Xu
Published: 202510.1038/s41590-025-02333-1
Abstract
Serine/threonine kinase 40 (STK40) belongs to the Tribbles family of pseudokinases, which serve as substrate adaptors for the CRL4COP1/DET1 E3 ubiquitin ligase complex. Tribbles-1 and Tribbles-2 promote the degradation of CCAAT/enhancer-binding prote…
Preview only. Read the full abstract at the source