Nature immunologyInterferon Regulatory FactorsCD8-Positive T-LymphocytesCell DifferentiationAnimalsMice
Analysis of the three-dimensional genome of exhausted CD8+ T cells reveals a critical role of IRF8 in their differentiation and functions in cancer.
Ruifeng Li, Kun Wei, Qinli Sun, Bowen Xie, Peng Wei, Tian Xie, Xinyi Guo, Yongzhen Chen, Birui Pan, Zixuan Zhao, Ling Ni, Chen Dong
Published: 202510.1038/s41590-025-02330-4
Abstract
CD8+ T cells are rendered exhausted in cancer, accompanied by extensive changes in the epigenome. However, whether and how higher-order chromatin organization is involved in exhausted CD8+ T cell differentiation is unclear. Here, we show extensive ch…
Preview only. Read the full abstract at the source