Nature immunologyHumansInterleukin-1betaNLR FamilyPyrin Domain-Containing 3 ProteinMonocytes
Single-cell analysis reveals cell death as driver of NLRP3-mediated secretion of IL-1β in human monocytes.
Lieselotte Vande Walle, Kentaro Kato, Mai Yamagishi, Takashi Kamatani, Alex Vervaeke, Rosa Martín-Pérez, Masaki Shimizu, Takumi Takizawa, Junko Takita, Ryuta Nishikomori, Osamu Ohara, Kazushi Izawa, Yoshitaka Shirasaki, Mohamed Lamkanfi
Published: 202510.1038/s41590-025-02319-z
Abstract
Interleukin-1β (IL-1β) is a key proinflammatory cytokine with critical roles in infections and inflammatory diseases, yet the mechanisms regulating its release from human monocytes remain unclear. Here we used a suite of single-cell approaches, inclu…
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