Nature chemical biology
Autopalmitoylation of IDH1-R132H regulates its neomorphic activity in cancer cells.
Lu Hu, Jinyu Lin, Liping Sun, Alison M Berezuk, Katharine S Tuttle, Xing Zhu, Hyuk-Soo Seo, Sirano Dhe-Paganon, Pan Li, Yang Sun, Lisheng Ni, Jianan Zhang, Dazhi Tan, Hiroaki Wakimoto, Daniel P Cahill
Published: 202610.1038/s41589-025-02131-8
Abstract
Gain-of-function mutations of isocitrate dehydrogenase 1 (IDH1) lead to oncometabolite (R)-2-hydroxyglutarate production, contributing to the tumorigenesis of multiple human cancers. While fatty acid biosynthesis is critical for IDH1-mutant tumor gro…
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