Nature chemical biology
Unique gluing effect of ASXL1 K351 monoubiquitination stimulates the PR-DUB activity.
Tianyi Zhang, Jiqing Zheng, Zebing Tong, Zhiheng Deng, Zaozhen He, Xiangwei Wu, Miao Wang, Yunxiang Du, Ziyu Xu, Shixian Tao, Shizhang Wan, Xiaolin Tian, Haiteng Deng, Man Pan, Huasong Ai
Published: 202610.1038/s41589-025-02126-5
Abstract
Protein ubiquitination critically regulates biological processes through both proteolytic and nonproteolytic mechanisms. While classically known for protein degradation, ubiquitination also modulates enzymatic activity. However, current mechanisms of…
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