Nature chemical biology
Rapid evolution of a highly efficient RNA polymerase by homologous recombination.
Esau L Medina, Victoria A Maola, Mohammad Hajjar, Grace K Ko, Ethan J Ho, Alexandria R Horton, Nicholas Chim, John C Chaput
Published: 202610.1038/s41589-025-02124-7
Abstract
Engineering DNA polymerases to efficiently synthesize artificial or noncognate nucleic acids remains an essential challenge in synthetic biology. Here we describe an evolutionary campaign designed to convert a family of highly selective DNA polymeras…
Preview only. Read the full abstract at the source