Nature chemical biology
Allosteric activation of RNF20/RNF40-RAD6A-mediated H2BK120 monoubiquitylation by H2BS112 GlcNAcylation.
Zhiheng Deng, Shixian Tao, Yunxiang Du, Yulei Li, Liying Zhang, Qiang Shi, Xiaoru Du, Maoshen Sun, Zebin Tong, Man Pan, Lei Liu, Huasong Ai
Published: 202610.1038/s41589-025-02109-6
Abstract
The activation of H2B K120 monoubiquitylation (H2BK120ub) by H2B S112 GlcNAcylation (H2BS112GlcNAc) has an important role in regulating transcriptional activation, yet its mechanism remains unclear. Here we chemically synthesized H2BS112GlcNAc-modifi…
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